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The ongoing and completed clinical trials involving representative natural compounds (e.g., curcumin, resveratrol, and related phytochemicals), including their clinical indications, trial phases, and key outcomes

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On the GLP-1R, native GLP-1(7-36) ( D ) has a complex profile with a bi-phasic kinetic response at high ligand concentrations, while TZP ( F ) is monophasic even at the highest tested concentrations

The insulin receptor substrate-1 (IRS-1)/PI3K/Akt signalling axis is disrupted, contributing to reduced glucose transport and leading to hyperglycaemia [12]

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Common Genetic Variation in the Melatonin Receptor 1B Gene (MTNR1B) Is Associated with Decreased Early-Phase Insulin Response.