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Back to Journals Drug Design, Development and Therapy Volume 19 The Clinical Application of GLP-1RAs and GLP-1/GIP Dual Receptor Agonists Based on Pharmacological Mechanisms: A Review Authors Liu Z, Yu S, Jin X, Sheng L, YanMu MR, Gao J, Lu J, Lei T Received 11 August 2025 Accepted for publication 15 November 2025 Published 22 November 2025 Volume 2025:19 Pages 1038310409 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Anastasios Lymperopoulos Zhao Liu, 1 Shanshan Yu, 1 Xinyan Jin, 1 Luguang Sheng, 2 Mai Re YanMu, 1 Jie Gao, 1 Jun Lu, 1 Tao Lei 1 1 Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, Peoples Republic of China

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The Three Patent Cliff Waves: The US market $20+ billion in annual GLP-1 sales and counting stays protected until at least 2031

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However, deletion of lncRNA UCA1 decreases the levels of TNF-, IL-6 and IL-1 and reduces the apoptosis of intestinal epithelial cells, suggesting that knockdown of lncRNA UCA1 may alleviate the symptoms of UC

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Nevertheless, a study conducted on the LITMUS consortium European suggested that 98% of the current registry cohort of patients with NAFLD would meet the new criteria for MASLD [52]

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Neuropeptides 38, 175188

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