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SGLT2 inhibitors have demonstrated robust reductions in hospitalisation for heart failure across risk groups, with cardiovascular death benefits most clearly established in heart failure trials

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Collectively, these data suggest that enrichment of Escherichia-Shigella is not only a compositional hallmark of RE-associated dysbiosis but also a functionally relevant pathobiont shift that couples barrier collapse with IL-6-JAK/STAT3-driven and TLR4-NF-B-driven increased inflammatory responses, thereby sustaining a feedforward injury loop 120

7 Cell Adhesion Cadherin-mediated intercellular interactions suppress ferroptosis by activating intracellular NF2

10.3389/fphar.2022.897791 56 LeeH