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All evidence comes from mouse models and cell cultures

Embryonic fibroblasts from Gpx4(+/) mice: A novel model for studying the role of membrane peroxidation in biological processes

The Journal of neuroscience : the official journal of the Society for Neuroscience 2016;36, 5448-5461, doi:10.1523/jneurosci.4247-15.2016

As expected, the death of non-xCT-overexpressing cells was almost completely rescued by the lipophilic radical scavenger liproxstatin-1 (Extended Data Fig

NielsenNMRostgaardKRasmussenSKoch-HenriksenNStormHHMelbyeMet al

Jan 1 2018;187(1):60-74