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Better animal models are needed in order to recapitulate human disease, diverse antigenic history (mixed infection and vaccination) and immune phenomena such as original antigenic sin and imprinting

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Patients receiving telitacicept, particularly at a dosage of 240 mg weekly, experienced a substantial reduction in proteinuria, with a mean decrease of 49% from baseline, which was statistically significant compared to the placebo group (P = 0.013)

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The absorption challenge is inherent to the molecule itself, not just the delivery format

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