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The metabolic phenotype of SLC25A45 KO mice can be restored by carnitine supplementation, supporting the crucial role of SLC25A45 for carnitine biosynthesis

GLP1RA improve blood pressure and reduce CV event risk, likely through central and peripheral autonomic regulation, increased natriuresis, and the presence of these genes in CV tissues (e.g., endothelial cells, vascular smooth muscle cells, resistance arteries) 53

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Common nonclinical applications include receptor binding studies, functional assay development, and analytical method validation