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Extrapolating from animal research to human effects requires significant caution, as metabolic pathways don't always translate directly between species

doi: 10.1038/s41416-022-02096-8

Now, caveat, Lilly indicated phase 3 would include slow titration, so these results may change but the slowest titration arm still reached nearly 17% weight loss without a plateau

Merio, R

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Variable responses are likely due to a combination of modifiable (i.e., dose, duration, co-supplementation, etc.) and non-modifiable (i.e., age, gender, disease) factors, although herein we will focus on the modifiable factors through which individuals might optimize muscle carnosine loading