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Although the serotonergic pathway may create a physiological decrease in sexual desire for patients taking GLP-1 agonists, we postulate that this diminishing influence of GLP-1 agonism is both compounded by factors such as undesirable side effects and increased SHBG and offset by the enhancing influences on sexual desire such as increased total testosterone, and improved vascular reactivity and mood

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[DOI] [PubMed] [Google Scholar] 10.Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension

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