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The genetic instability ulteriorly leads to genetic alterations in cells, such as somatic mutations of PIK3CA and TP53 , which are non-inherited

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For how these effects fit into the receptor biology, discovery, and pipeline behind the class, see the wider view of GLP-1 and metabolic disease

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Notably, emerging clinical evidence, including RCTs of TCM formulations and observational studies linking SCFA levels with renal function, supports the translational potential of this therapeutic strategy

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