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anginosus [185]

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Despite this contraindication, the human relevance of GLP-1RA induced MTC in rodents has not been proven

Several epidemiological studies, Mendelian randomization studies, and randomized controlled trials demonstrated a log-linear relationship between the absolute changes in plasma LDL and the risk of atherosclerotic cardiovascular diseases (ASCVDs) [14,15], which include coronary heart disease, cerebrovascular disease, peripheral artery disease, and aortic atherosclerotic disease

Existing GLP1R agonists come with boxed warnings of thyroid cancer and pancreatitis, based mainly on rodent studies, where the effects of GLP1R agonism have noted species differences (For example, weight loss in rodents is mainly due to increased energy expenditure, whereas in humans it occurs via less food intake [54] )

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