glp 1 and kidney function Design discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis GLP1 Receptor Agonists vs SGLT2-I

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A few highlights: Accelerated eGFR decline during the year preceding a heart failure event Slower decline afterward but still exacerbated A parallel between eGFR slope and NYHA class, suggesting the kidney may be signaling congestion early These findings call for a shift in practice: instead of relying on static eGFR thresholds, tracking its trajectory over time could help us identify at-risk patients sooner and intervene before hospitalization

ABBV-3373, as the first anti-inflammatory ADC to enter clinical trials, couples a novel glucocorticoid receptor modulator (GRM) with an anti-TNF monoclonal antibody via an MP-Ala-Ala linker, achieving targeted delivery of glucocorticoids [75]