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Description

The combination of large extracellular domains (ECD), extended orthosteric binding sites, and conformational flexibility makes class B1 GPCRs interesting but challenging targets for rational ligand discovery and particularly demanding benchmarks for computational ligand design and virtual screening methodologies (Aksu et al., 2024

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2 Transporter-Mediated DDIs Efflux transporters (P-gp, BCRP) Uptake transporters (OATP, OCT) Example: P-gp inhibition increasing digoxin exposure

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Supply and oral drugs the difficulty of manufacturing GLP-1s could be addressed by a company demonstrating efficacy, and more importantly, safety of an oral non-peptide GLP-1

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Although 10 nM BCTC blocked the CAP-induced TRPV1 currents, 20 nM BCTC did not significantly potentiate this TRPV1-inhibiting effect (Fig

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