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Prior to all self-administration sessions, experimenters flushed the catheters of the animals with a solution of Cefazolin in heparinized saline, prepared following the procedure described in the previous section

Because of this, it is called a triple agonist

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However, whereas the majority of hepatotoxic compounds cause centrilobular injury, some xenobiotics, such as allyl formage, elemental phosphorus, and allyl alcohol, preferentially damage periportal hepatocytes, presumably as a result of rapid first-pass uptake by these upstream hepatocytes