Abstract Since type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimers disease (AD) and both have the same pathogenesis (e.g., insulin resistance), drugs used to treat T2DM have been gradually found to reduce the progression of AD in AD models
In clinical trials, it has demonstrated superior efficacy, with participants on the highest dose achieving an average weight loss of approximately 21% over 72 weeks
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Instead, it appears to be an indirect consequence of the metabolic and physiological changes that occur during treatment
Similarly, the ICV infusion of liraglutide stimulates BAT thermogenesis and white adipose tissue browning