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In 2015, the US Food and Drug Administration granted accelerated approval for trabectedin for treating these cancers in patients with advanced soft tissue cancer who failed to respond to chemotherapy

If cost or sideeffects drive high discontinuation rates, any underwriting or pricing assumptions based on sustained use could quickly become outdated

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However, the profound weight loss observed with GLP-1 RA treatment (as well as other approaches resulting in weight loss through appetite suppression, such as bariatric surgery) raises some concerns

Mounjaro, a newer option, is designed to tackle both diabetes management and weight loss simultaneously

doi: 10.1007/BF02766832