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J Steroid Biochem Mol Biol (2021) 213:105954

How Synthetic HGH Works in the Body When synthetic HGH is injected, it enters the bloodstream directly and raises circulating levels of both growth hormone and IGF-1 (insulin-like growth factor-1), a hormone produced primarily by the liver in response to growth hormone that mediates many of HGHs effects on muscle and tissue growth

However, this has not been trialed longitudinally with dementia patients to demonstrate safety and efficacy

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Poletini MO, de Assis LV, Moraes MN, Castrucci AM (2016) Estradiol differently affects melanin synthesis of malignant and normal melanocytes: a relationship with clock and clock-controlled genes