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Of note, exendin-4 was serendipitously discovered in the saliva of the Gila monster ( Heloderma suspectum ) and was revealed to be a GLP-1 analog that is resistant to DPP-4 action in 1992, even before the mechanism of GLP-1 degradation was identified [7]
50-64y: 15030.63, 14844.56, 14714.16, 15320.28 (0.12, 0.64)
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GLP-1 receptor agonists enhance insulin secretion in response to elevated blood glucose, suppress glucagon release, slow gastric emptying, and reduce appetite through effects on the central nervous system
Davies, D
Cardiovascular Protection GLP-1s lower inflammation, improve endothelial function, and reduce cardiovascular eventsindependent of weight loss
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