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2-Methylbutyryl-CoA can also be converted to its carnitine derivative, 2-methylbutrylcarnitine (2MBC) via the action of carnitine O -acetyltransferase encoded by the CRAT gene

Tirzepatides dual pathway, according to Dr Tan, makes the medication more potent than semaglutide, with studies showing tirzepatide to be more effective than semaglutide for the treatment of obesity

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Constipation: common but manageable Constipation is frequently reported with GLP-1 therapy and may worsen with: Low fibre intake Reduced food intake Inadequate hydration A sedentary lifestyle Helpful measures may include: Adequate water intake Fibre-rich fruits and vegetables Walking or light physical activity Isabgol or fibre supplementation if medically appropriate To reduce nausea, many patients find relief by switching to lighter regional Indian meals and smaller portions during the first few weeks