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Description

Semaglutide, commonly known by brand names like Ozempic and WeGovy, is a medication that was originally designed to help people living with type 2 diabetes mellitus

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For individuals with obesity and comorbid psychological symptoms, combined outcomes such as clinically significant weight loss (e.g., 10%) and reduced binge-eating frequency or depressive symptoms are reasonable targets

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Semaglutide FDA-approved uses for each brand are Ozempic (type 2 diabetes, reducing cardiovascular event risks, reducing risk of kidney function decline), Wegovy (weight management, reducing cardiovascular event risks, non-cirrhotic MASH), and Rybelsus (type 2 diabetes, reducing cardiovascular event risks)

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Details of clinical codes for eligibility criteria, exposure, outcomes, and confounders are in Supplementary Table S1 in the Supplementary Appendix

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Failing to do so could put the patients health at risk

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Participants who began at lower doses and increased incrementally reported better tolerability than those who escalated more rapidly

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