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Cells were incubated with a pA-Tn5 adapter complex in Dig-med buffer (0.01% Digitonin

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In addition, the high penetration level through the stratum corneum alone can be explained by the fact that there was no tissue retention from underlying skin that may have limited penetration

Withdrawal rates due to adverse effects serve as a practical measure of real-world tolerability, as they reflect whether side effects are bothersome enough to outweigh potential benefits