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In this article, well break down how compounded and brand-name GLP-1s compare and why one woman (Sarah, 44) switched to Josie after brand-name side effects hit too hard, too fast

(%) Sweden Denmark GLP-1 receptor agonists (n = 77 495) Before weighting After weighting a GLP-1 receptor agonists (n = 47 022) Before weighting After weighting a SGLT2 inhibitors (n = 108 881) Standardized difference SGLT2 inhibitors, % Standardized difference SGLT2 inhibitors (n = 65 155) Standardized difference SGLT2 inhibitors, % Standardized difference History of psychiatric conditions or use of antidepressants Current use of antidepressants (past 6 mo) 14 705 (19.0) 15 992 (14.7) 11.5 19.5 1.2 7665 (16.3) 8196 (12.6) 10.6 16.4 0.3 Previous use of antidepressants (past 10 y but not within 6 mo) 25 760 (33.2) 29 556 (27.1) 13.3 33.9 1.4 14 711 (31.3) 16446 (25.2) 13.5 31.5 0.5 Depression or anxiety-related disorder within past y 1975 (2.5) 1673 (1.5) 7.2 2.6 0.6 367 (0.8) 389 (0.6) 2.2 0.7 0.4 Previous depression or anxiety-related disorder (at any time before cohort entry, including past y) 9947 (12.8) 9896 (9.1) 12.0 13.2 1.1 2246 (4.8) 2240 (3.4) 6.7 4.8 0.1 Drug misuse within past y 295 (0.4) 276 (0.3) 2.3 0.4 0.4 242 (0.5) 207 (0.3) 3.1 0.6 1.1 Previous drug misuse (at any time before cohort entry, including past y) 1346 (1.7) 1272 (1.2) 4.8 1.9 1.1 699 (1.5) 657 (1.0) 4.3 1.7 1.4 Alcohol-related disorders within past y 629 (0.8) 707 (0.6) 1.9 0.9 0.7 380 (0.8) 437 (0.7) 1.6 0.8 0.4 Previous alcohol-related disorders (at any time before cohort entry, including past y) 2922 (3.8) 3578 (3.3) 2.6 3.9 0.4 1650 (3.5) 2208 (3.4) 0.7 3.5 0.1 Previous self-harm 1591 (2.1) 1548 (1.4) 4.8 2.1 0.5 79 (0.2) 91 (0.1) 0.7 0.1 0.5 Schizophrenia 1519 (2.0) 1673 (1.5) 3.2 2.1 0.7 611 (1.3) 598 (0.9) 3.6 1.2 0.5 Behavioral syndromes associated with physiological disturbances and physical factors 1067 (1.4) 919 (0.8) 5.1 1.3 0.4 176 (0.4) 162 (0.2) 2.3 0.3 0.5 Disorders of adult personality and behavior 1155 (1.5) 891 (0.8) 6.3 1.6 1.0 272 (0.6) 164 (0.3) 5.1 0.6 0.0 Other psychiatric diagnoses 2158 (2.8) 1788 (1.6) 7.8 3.0 1.0 358 (0.8) 260 (0.4) 4.8 0.8 0.3 Outpatient visit for psychiatric diagnosis during past y 4301 (5.6) 3877 (3.6) 9.6 5.8 1.0 811 (1.7) 754 (1.2) 4.8 1.7 0.6 Hospitalization for psychiatric diagnosis during past y 755 (1.0) 754 (0.7) 3.1 1.0 0.2 441 (0.9) 448 (0.7) 2.8 0.9 0.6 Outpatient visit for psychiatric diagnosis (but not during past y) 10 546 (13.6) 10 376 (9.5) 12.8 14.0 1.2 1502 (3.2) 1505 (2.3) 5.4 3.1 0.7 Hospitalization for psychiatric diagnosis (but not during past y) 3655 (4.7) 3748 (3.4) 6.4 4.9 0.8 926 (2.0) 981 (1.5) 3.5 1.9 0.2 Other medical history Cardiovascular disease 22 271 (28.7) 44 685 (41.0) 26.0 27.9 1.8 13 484 (28.7) 23869 (36.6) 17.0 29.4 1.7 Diabetes complications 28 500 (36.8) 37 921 (34.8) 4.1 37.3 1.1 14 609 (31.1) 19 577 (30.0) 2.2 33.5 5.3 Obesity diagnosis 14 600 (18.8) 10 726 (9.9) 25.9 19.1 0.8 10 813 (23.0) 8169 (12.5) 27.6 23.4 0.9 Thyroid disease 1456 (1.9) 1524 (1.4) 3.8 1.9 0.2 1134 (2.4) 1238 (1.9) 3.5 2.4 0.2 Prescription drug use in past y -Blocker 30 293 (39.1) 50 425 (46.3) 14.6 38.7 0.9 11 649 (24.8) 20 505 (31.5) 14.9 25.6 1.9 Opiate 13 994 (18.1) 15 743 (14.5) 9.8 18.6 1.3 8302 (17.7) 9470 (14.5) 8.5 18.2 1.4 Antipsychotic 3017 (3.9) 2979 (2.7) 6.5 4.1 1.0 2473 (5.3) 2751 (4.2) 4.9 5.4 0.5 Anxiolytic 7287 (9.4) 8462 (7.8) 5.8 9.6 0.7 1966 (4.2) 2348 (3.6) 3.0 4.3 0.7 Hypnotic or sedative 12 688 (16.4) 15 578 (14.3) 5.7 16.5 0.4 3505 (7.5) 4165 (6.4) 4.2 7.4 0.3 ADHD medications 702 (0.9) 460 (0.4) 6.0 0.9 0.4 402 (0.9) 284 (0.4) 5.2 0.8 0.5 Oral glucocorticoid 7348(9.5) 9525 (8.7) 2.5 9.6 0.3 2974 (6.3) 3893 (6.0) 1.5 6.4 0.5 (continued) Research Original Investigation GLP-1 ReceptorAgonist Use and Risk of Suicide Death E6 JAMA Internal Medicine Published online September 3, 2024 (Reprinted) jamainternalmedicine.com Table 1

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