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No single clinical feature confirms type 1 diabetes in isolation [9, 10]

Clinically, physiologic hyperpigmentation does not show the velvety, leathery texture of acanthosis nigricans and does not display papillomatosis and hyperkeratosis [9]

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I was hopeful but cautious, as the outcome underscores just how difficult this disease remains to treat. Rasouli, who was not part of the study, noted that many participants may have already experienced irreversible neuron loss by the time they enrolled

doi: 10.1016/j.pnpbp.2015.11.012 69 HabibA