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Class-related safety considerations include pancreatitis, gallbladder disease, increased heart rate, and a precautionary contraindication in patients with a history of medullary thyroid carcinoma or MEN2

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2012), our observation that APAP decreased GJ abundance suggested that hepatocytes mount a defense against the spread of oxidative stress molecules within liver tissue during the early stages of APAP exposure by reducing the expression of Cx32 (and consequently GJs)

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