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The development of exendin-4 into the diabetes drug exenatide started the GLP-1RA, or GLP-1 receptor agonist, race

Another side effect of taking GLP-1 medication is loss of muscle, known as sarcopenia

Always seek the advice of a qualified Specialist Endocrinologist or healthcare professional regarding a medical condition

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According to the International Foundation of Employee Benefit Plans, as of 2025: 55% of employers cover GLP-1 medications only for diabetes through their health plans, down from 57%in 2024 36% cover GLP-1 medications for both diabetes and weight loss through their health plans, up from 34%in 2024 Other sources report a much higher GLP-1 coverage for weight loss, between 49% and 57% among employers

Therefore, anyone using GLP-1s should require oversight of nutrition: adequate protein, micronutrients, healthy fats, fiber, and perhaps supplementation/support as needed