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Cells and animals dont have human ovarian complexity and long-term exposures

IGF-1 can directly support thyroid hormone production, and organ-specific IGF-1 signal loss reduces thyroid hormone and significantly increases thyroid stimulating hormone (TSH) levels (31)

Serum insulin-like growth factor 1 (IGF-1) levels, which are a substitute for GH levels, were compared to sexual function scores in 65 men who filled out the Sexual Health Inventory for Men (SHIM) and the Expanded Prostate Cancer Index Composite (EPIC) questionnaires and had their testosterone and IGF-1 levels checked

doi:10.1016/j.jns.2006.07.009

Peters SP

In BV2 microglia cells treated with okra, TNF- and IL-1 production was also markedly reduced