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It is a selective growth hormone secretagogue receptor agonist, meaning it stimulates GH release through a different receptor pathway than GHRH

The peptides most commonly discussed for ED work through several proposed mechanisms

Biosocial variation in treatment response to GLP-1s: implications for clinical care and health policy

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Hypoglycemia (Low Blood Sugar) Because IGF-1 mimics insulin, it can cause increased glucose uptake into cells which, without adequate carb intake, may lead to symptoms of hypoglycemia (shakiness, fatigue, dizziness)

This is why retatrutide has generated so much excitement