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specifically, biochemical deterioration observed at L5S1 is more important in younger individuals than older ones

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Tirzepatide works by activating both the GLP-1 receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor

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LHCGR engagement activates Gs-coupled adenylyl cyclase, driving cAMP accumulation and PKA-mediated phosphorylation of downstream steroidogenic targets including CYP11A1, CYP17A1, and 3-HSD