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However, PAI-1 carbonylation has been demonstrated to influence its functional activity and structural stability [38], therefore carbonylated PAI-1 may exhibit reduced activity, and we hypothesize that it could trigger a compensatory mechanism leading to an increase in its overall concentration observed in our cohort

This peptide appears to exhibit a high selectivity for GHSR, potentially without interfering with other hormones

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(a) Ces effets ne sont cependant obtenus que si les patients modifient leurs habitudes (alimentation et activit physique), sils adhrent au traitement (=sils prennent la dose prescrite la frquence prescrite), et sils le prennent long terme (car on reprend du poids la fin du traitement)

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