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However, findings in a systematic review and meta-analysis of prolonged NSAID use (ranging from one to seven years) indicated NSAIDs accelerate OA progression

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It should be noted that, among other physiological effects, chronic hyperglycemia leads to an imbalance of the oxidative status, affecting central and peripheral nervous system

[39] Amirato, G.R., Borges, J.O., Marques, D.L., Santos, J.M.B., Santos, C.A.F., Andrade, M.S

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