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Recommendations Intensification Intensification of insulin therapy should be considered when patients fail to achieve glycemic goals even after optimal dose titration (Grade A, EL I) Intensification with premix insulin twice daily or thrice daily, insulin co-formulation-based regimen, prandial insulin (basal plus or basal bolus) with the largest meal of the day, or GLP-1 RA

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Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline

(Lancet 2015) A postoperative strategy combining early colonoscopy + step-up therapy reduced endoscopic recurrence vs standard drug therapy alone

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Wegovy showed a greater incidence of gastrointestinal side effects