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Stimulation of de novo glutathione synthesis by NFT concentrations in this range was observed in HepG2 cells, PHHs, or human neuronal cells, but not to the same extent in other cell types such as human iPSC-derived astrocytes

The search methodology included terms as oxidative stress, reactive oxygen species, biomarkers, hypertension, endothelial dysfunction, mitochondrial dysfunction, diabetes, -cell damage, vascular dysfunction, hyperglycemia, insulin resistance, vascular complications, diabetic neuropathies, disease progression, antioxidant therapy, clinical trials, and precision redox medicine

Skin aging is characterized by increased wrinkles, senile spots, dryness, thinning, and decreased elasticity (21)

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It was a rigorous, gold-standard medical trial participants were randomly assigned to different doses or a placebo, and neither the participants nor the doctors knew who was getting what