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Since reduced anti-coagulant properties and increased pro-inflammatory mediators and reactive oxygen species play important roles in the development of both endothelial dysfunction and atherosclerosis, the association between the two is almost ubiquitous [88]

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Echocardiographic analysis was performed using the Vevo 3100 high-resolution in-vivo imaging system (Fujifilm VisualSonics, Toronto, Canada) with an ultrahigh-frequency MX400 transducer (30 MHz, 55 frames per second)