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This regenerates NAD + to sustain ongoing glycolysis, particularly under hypoxia, while simultaneously clearing intracellular protons (H + ) to mitigate acidosis, as observed in the TME

ROS levels are usually tightly controlled through NNT and the activity of peroxidases that convert ROS to water as also illustrated in Figure 1

Known as the master antioxidant, glutathione supports and enhances the effects of other antioxidants

Lobello et al., 2016), which might be due to irons induction of excess ROS (Zhang et al., 2020e)

The study measured objective skin lightening using a mexameter not subjective assessment