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The researchers thus hypothesized that blocking NNMT could open a novel path to treating obesity and its metabolic complications [1, 2]

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The sequence (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) was isolated by Croatian researcher Predrag Sikiric and his colleagues in the 1990s, who discovered that this fragment retained the protective biological activity of the parent gastric compound

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Synephrine and octopamine may be present in small amounts in legitimate citrus extracts such as citrus aurantium or sinensis