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Some studies look at intermittent dosing schedules

It usually takes five to six half-lives for most of the drug to leave the system

Clin Pharmacol Ther 1963

The findings may help explain why metabolic treatmentsincluding GLP-1-based drugsdo not necessarily have the same effects across different neurodegenerative diseases

Additionally, GLP-1 RAs may exert antihypertensive effects through reduced carotid body excitability and inhibition of sympathetic nerve activation 42

Sub-references of the articles identified relying on keywords were sought and these were scrutinised too