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In the initial inflammatory phase, IL-1 facilitates neutrophil infiltration and macrophage activation, whereas IL-18 supports angiogenesis and epithelial cell proliferation [30]

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In studies involving mouse models of inflammation, GLP-1RAs facilitate the proliferation of Firmicutes that produce SCFAs and generate Interleukin-22 (IL-22), while also suppressing harmful bacteria like Staphylococcus, which aligns with the observed reduction in epithelial cell death and the activation of the interferon signaling pathway [106,107]

Novo Nordisks Rybelsus was the first oral GLP-1 receptor agonist product approved by the FDA for the treatment of type 2 diabetes

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