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doi: 10.1038/nrendo.2016.67 103 LiuHXuYHuF

When SELENOP is knocked out of a mouse model, irreversible neurological dysfunction such as inability to walk and stiff gait was noticed very soon after birth (Hill et al., 2004)

Meng Z, Yang M, Wen H, Zhou S, Xiong C, Wang Y

10.1038/375061a0 73 ColletJ.-F.MessensJ

But access and affordability came with a workaround that's now under serious regulatory fire: compounding pharmacies

The most common scenario for major drugs is a five-year SPC, since most drugs take more than 10 years from patent filing to EU marketing authorization