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Sodium-glucose cotransporter 2 (SGLT2) inhibitors Glucose in the blood passes through the kidneys, where the body either excretes it in urine or reabsorbs it back into the blood

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J R Stat Soc Ser A Stat Soc 177

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Other non-selective alterations of water quality, such as reducing dissolved oxygen levels or altering pH, could also have a deleterious impact on native fish, invertebrates, and other fauna or flora, and their potential harmful effects should therefore be evaluated thoroughly