retatrutide triple agonist phase 2 nejm 2023 obesity results (not yet approved in US but people using anyway) promises even potentially greater weight loss amongst the GLP1 drugs. https://www.nejm .org/doi/full/10.1056/NEJMoa2301972 Triple G Agonists – Retatrutide.

Wegovy: GoodRx cites a list price around $1,350 for 28 days (article updated recently)

Chris Boshoff, MD, PhD, Chief Scientific Officer and President, Research and Development at Pfizer, commented: Cardiovascular and metabolic diseases including obesity remain important areas of unmet medical need, and we plan to continue applying our global capabilities to advance a pipeline of investigational treatments that have the potential to fill critical gaps in patient care, including continued development of our oral GIPR antagonist candidate and other earlier obesity programmes. Future directions in metabolic disease Despite this setback, Pfizer confirmed its ongoing commitment to metabolic disease research, with particular focus on its oral gastric inhibitory polypeptide receptor (GIPR) antagonist candidate and other earlier-stage obesity programmes

Some people may experience mild side effects like flushing, headache, or nasal irritation

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Fat slows gastric emptying further

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