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Chronic low-grade inflammation contributes to obesity-related comorbidities [123, 124], and the MD has consistently demonstrated immunomodulatory effects, even in the absence of weight loss [123, 124]
The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice
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Similarly, in the FIGARO-DKD trial (Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease trial), the residual risk of the primary composite end point of death from CV causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure was 12.4% [11, 13]
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