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MGF and Cardiac Function Cross-Species Validation Delivery of the MGF E-domain peptide via peptide-eluting polymeric microstructures to post-MI mice decreased mortality, ameliorated the decline in haemodynamics, and delayed cardiac decompensation with the beneficial cardiovascular effects of the stabilised E-domain peptide confirmed across rodent and large animal models, providing a platform for understanding local tissue IGF-1 autocrine/paracrine modulation in cardiac repair research