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Hepatology (2018) 67:32857

Inhibition of the hERG channel can cause fatal cardiac arrhythmias in humans ( 27 )

Action in the Pancreas If we look at the action of GLP-1 at the pancreas we see that it increases the size of the Islets of Langerhans, which are the areas in the pancreas where the beta cells are found, which produces all of these hormones, not just insulin but glucagon as well

Preparing for Your Injection Start by washing your hands well with warm water and soap, and dry them with a clean towel

This is why injectable GLP-1 medications produce such dramatic effects on appetite and weight

Abbreviations GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist T2DM: Type-2 diabetes mellitus DPP-4: Dipeptidyl peptidase 4 HbA1c: Hemoglobin A1c NASH: Non-alcoholic steatohepatitis NAFLD: Non-alcoholic fatty liver disease Camp: Cyclic adenosine monophosphate PKA: Protein kinase A EPAC: Exchange protein directly activated by cAMP PI3K: Phosphoinositide 3-kinase PYY: Peptide YY CCK: Cholecystokinin GLUT4: Glucose transporter type 4 mTORC1: Mammalian target of rapamycin complex 1 References Ahrn B (2015) Hepato-incretin function of GLP-1: novel concept and target in type 1 diabetes