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The biological effects happen quickly, but weight loss on a scale is delayed because initial changes involve fluid retention, hormonal shifts, and metabolic adjustment

doi:10.2169/internalmedicine.52.0053 28.Altrup U, Gerlach G, Reith H, Said M, Speckmann E

Image credits: Alexandra Wyman / Getty#2 Post Malone The first and only male on this list, Austin Post, better known as Post Malone, got accused of using semaglutide after losing nearly 60 pounds and addressed the rumors on an appearance on The Howard Stern Show."No, sir

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Contrave side effects The most common side effects include: Nausea Constipation Diarrhea Headache Vomiting Dizziness Insomnia Dry mouth Rare but serious side effects include an allergic reaction, seizures, liver damage, increased blood pressure or heart rate, and vision problems