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In addition, obesity-associated adipose tissue inflammation further exacerbates CNS inflammation, creating a vicious cycle of metabolisminflammationneurodegeneration (Chen et al., 2024

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282,283 TLR4 is one of the most important and widely involved members of the TLR family, and it is also a key signaling molecule in the treatment of UC by targeting the TLR pathway

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Endocrinology 2011;152:4072-9.ArticlePubMed 96

Given that NADPH is reduced by Dox treatment (Fig