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As you lose weight, you become less insulin-resistant, However, there is a concern about weight regain once the medication is discontinued

In Phase 2 trials, treatment with survodutide led to greater reductions in both HbA1c levels and body weight compared to placebo after 16 weeks

10.1080/07315724.2020.1789518 J Am Coll Nutr

Understanding the Beyond-Use Date (BUD) Unlike branded medications that have expiration dates (which can be a year or more away), compounded medications have a Beyond-Use Date, or BUD

I didnt notice any immediate benefits in terms of cognition or mood

That is the absolute ceiling for the 21-day room temperature allowance