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OSMOTIC LAXATIVES Mechanism Draw water into bowel lumen Examples Lactulose Magnesium sulfate Magnesium hydroxide Polyethylene glycol Uses Acute constipation Hepatic encephalopathy (lactulose) Side Effects Diarrhea Electrolyte imbalance 4

Indeed, dual GLP-1 ligands that activate the GLP-1R but simultaneously block the GIPR (AMG133 or maridebart cafraglutide, MariTide ) are currently in clinical trials for obesity/weight loss and seem to work as well as (if not even better than) dual GLP-1R/GIPR agonists, such as tirzepatide (Zepbound ) (see below) [52]

Cesar et al., Journal of Medicinal Food, 2022) Reducose Mulberry Leaf Extract

Pernicious anaemia occurs when the immune system attacks the healthy, specialised cells of the stomach that produce the intrinsic factor

A straightforward tirzepatide program for patients exploring weight manage

The length of the infusion is also important