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[DOI] [PMC free article] [PubMed] [Google Scholar] 150.Khalid M., Petroianu G., Adem A

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Therefore, it was suggested that betaine is neuroprotective, and dietary betaine supplementation may mitigate neurodegenerative disorders (Singhal et al., 2020

A randomized (159), double-blind, placebo-controlled trial involving 46 adult SLE patients (23 in the synbiotic group, 23 in the placebo group) showed that 60 days of synbiotic supplementation significantly increased butyrate metabolism, reduced the pro-inflammatory cytokine IL-6, and inhibited the elevation of hs-CRP

Clinical trials with a focus on improvement in fibrosis must similarly require no worsening in NASH

This combination represents a promising avenue for clinical application (107)