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Elevated Investigations: Blood glucose Serum and urine ketones Arterial blood gases (ABG) Electrolytes (especially potassium) Creatinine, urea (renal function) ECG (check for potassium disturbances) Full blood count, cultures (if infection suspected) Management: ABCDE approach treat urgently

One such peptide (-MSH) is particularly important for appetite control

It hits the receptor, runs the Gq/11 PLC IP3 calcium cascade, delivers a robust GH pulse, and essentially stops there

Aubrey B

In this study, we demonstrate that antagonizing SSTR2 and SSTR5 pharmacologically improved glucose tolerance by potentiating glucose-induced GLP-1 from the small intestine