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Nevertheless, these methodologies are associated with a high risk of infections, inflammation, high intracranial pressure, and damage to the brain tissue, and most of them are not suitable for chronic treatments [8,11]

Following nCRT, LARC patients usually undergo surgery and adjuvant chemotherapy (AC) to reduce the risk of recurrence or metastasis [69]

doi: 10.1016/j.ceca.2019.06.002

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The measurement and frequency indicated here simply reflect what most prescribers recommend for their patients