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The concentration of all metabolites was calculated relative to the unsuppressed water spectrum and expressed as %water signal (IMCL and EMCL) or in absolute concentration values (all other metabolites) calculated using the following formula: Where [M] is the metabolite concentration and [W] is the water concentration (55 M)

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481 This suggests that ACSL4 initiates a cascade that links ferroptosis to pyroptosis, thereby promoting cardiac hypertrophy and responding to the hemodynamic stress induced by aortic constriction

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